Prevnar 13 components (PCV13)

The vaccine is a homogeneous white suspension.
Prevnar 13 components in 1 dose (0.5 ml) are:

  • Pneumococcal polysaccharide serotype 1
  • Pneumococcal polysaccharide serotype 3
  • Pneumococcal polysaccharide serotype 4
  • Pneumococcal polysaccharide serotype 5
  • Pneumococcal polysaccharide serotype 6A
  • Pneumococcal polysaccharide serotype 6B
  • Pneumococcal polysaccharide serotype 7F
  • Pneumococcal polysaccharide serotype 9V
  • Pneumococcal polysaccharide serotype 14
  • Pneumococcal polysaccharide serotype 18C
  • Pneumococcal polysaccharide serotype 19A
  • Pneumococcal polysaccharide serotype 19F
  • Pneumococcal polysaccharide serotype 23F

Conjugated to CRM197 carrier protein, adsorbed on aluminium phosphate.
1 dose (0.5 ml) contains approximately 32 µg CRM197 carrier protein and 0.125 mg aluminium.

  • Sodium chloride
  • Succinic acid
  • Polysorbate 80
  • Water for injections

Prevnar 13, Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein) is a sterile suspension of saccharides of the capsular antigens of Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, individually linked to non-toxic diphtheria CRM197 protein. Each serotype is grown in soy peptone broth. The individual polysaccharides are purified through centrifugation, precipitation, ultrafiltration, and column chromatography. Prevnar 13 is a polyvalent vaccine like Pentacel.

CRM197 is a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197) grown in a casamino acids and yeast extract-based medium or in a chemically-defined medium. CRM197 is purified through ultrafiltration, ammonium sulfate precipitation, and ion-exchange chromatography.

Each 0.5 mL dose of the vaccine is formulated to contain approximately 2.2 μg of each of Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F, 23F saccharides, 4.4 μg of 6B saccharides, 34 μg CRM197 carrier protein, 100 μg polysorbate 80, 295 μg succinate buffer and 125 μg aluminum as aluminum phosphate adjuvant.

Prevnar 13, comprised of pneumococcal polysaccharides conjugated to a carrier protein
(CRM197), elicits a T-cell dependent immune response. Protein carrier-specific T-cells provide the signals needed for maturation of the B-cell response.

Source:
https://www.fda.gov/files/vaccines%2C%20blood%20%26%20biologics/published/Package-Insert——Prevnar-13.pdf
https://www.ema.europa.eu/en/documents/product-information/prevenar-13-epar-product-information_en.pdf

, , , , ,

Related posts

Pediarix components

Pediarix components are similar to Pentacel components. Single-dose, prefilled syringes containing a 0.5-mL suspension...

Pentacel components

Pentacel components are a bit more complex, if you compare it against monovalent vaccines...

Daptacel components

Daptacel is a sterile isotonic suspension of pertussis antigens and diphtheria and tetanus toxoids...

Rotarix components

Rotarix components are:

Human rotavirus RIX4414 strain (live, attenuated)**Produced on Vero cells

Powder:

SucroseDextranSorbitolAmino acidsDulbecco’s Modified Eagle...

Latest posts

Gardasil 9 components (HPV)

Gardasil 9 is a sterile suspension for intramuscular administration. Gardasil 9 components are:

Human Papillomavirus...

Pediarix components

Pediarix components are similar to Pentacel components. Single-dose, prefilled syringes containing a 0.5-mL suspension...

Pentacel components

Pentacel components are a bit more complex, if you compare it against monovalent vaccines...

Daptacel components

Daptacel is a sterile isotonic suspension of pertussis antigens and diphtheria and tetanus toxoids...