Janssen components (Johnson & Johnson Covid 19)

Janssen components are very different from Moderna Spikevax and Comirnaty (Pfizer-BioNTech). One dose (0.5 mL) contains:

  • Adenovirus type 26 encoding the SARS-CoV-2 spike glycoprotein* (Ad26.COV2-S), not less than 8.92 log10 infectious units (Inf.U)

*Produced in the PER.C6 TetR Cell Line and by recombinant DNA technology.

List of excipients:

10 vial pack

  • 2-hydroxypropyl-β-cyclodextrin (HBCD)
  • Citric acid monohydrate
  • Ethanol
  • Hydrochloric acid
  • Polysorbate-80
  • Sodium chloride
  • Sodium hydroxide
  • Trisodium citrate dihydrate
  • Water for injections

20 vial pack

  • 2-hydroxypropyl-β-cyclodextrin (HBCD)
  • Citric acid monohydrate
  • Ethanol
  • Hydrochloric acid
  • Polysorbate-80
  • Sodium chloride
  • Sodium hydroxide
  • Water for injections

This is a multi-dose vial which contains 5 doses of 0.5 mL. Colourless to slightly yellow, clear to very opalescent suspension (pH 6-6.4).

COVID-19 Vaccine Janssen is a monovalent vaccine composed of a recombinant, replicationincompetent human adenovirus type 26 vector that encodes a SARS-CoV-2 full-length spike (S) glycoprotein in a stabilised conformation. Like AstraZenica following administration, the S glycoprotein of SARSCoV-2 is transiently expressed, stimulating both neutralising and other functional S-specific antibodies, as well as cellular immune responses directed against the S antigen, which may contribute to protection against COVID-19.

Source:
https://www.fda.gov/media/146305/download#page=2
https://www.ema.europa.eu/en/documents/product-information/covid-19-vaccine-janssen-epar-product-information_en.pdf

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