AstraZenica components (Vaxzevria COVID-19 vaccine)

AstraZenica components are very different from Moderna Spikevax and Comirnaty (Pfizer-BioNTech). One dose (0.5 ml) contains:

  • Chimpanzee Adenovirus encoding the SARS-CoV-2 Spike glycoprotein (ChAdOx1-S) * , not less than 2.5 × 108 infectious units (Inf.U)
  • L-Histidine
  • L-Histidine hydrochloride monohydrate
  • Magnesium chloride hexahydrate
  • Polysorbate 80 (E 433)
  • Ethanol
  • Sucrose
  • Sodium chloride
  • Disodium edetate (dihydrate)
  • Water for injections

*Produced in genetically modified human embryonic kidney (HEK) 293 cells and by recombinant DNA technology.

These are multidose vials which contain 8 doses or 10 doses of 0.5 ml per vial. The suspension is colourless to slightly brown, clear to slightly opaque with a pH of 6.6.

Vaxzevria is a monovalent vaccine composed of a single recombinant, replication-deficient
chimpanzee adenovirus (ChAdOx1) vector encoding the S glycoprotein of SARS-CoV-2. The SARS-CoV-2 S immunogen in the vaccine is expressed in the trimeric pre-fusion conformation; the coding sequence has not been modified in order to stabilise the expressed S-protein in the pre-fusion conformation. Following administration, the S glycoprotein of SARS-CoV-2 is expressed locally 8 stimulating neutralising antibody and cellular immune responses, which may contribute to protection to COVID-19.

Source:
https://www.ema.europa.eu/en/documents/product-information/vaxzevria-previously-covid-19-vaccine-astrazeneca-epar-product-information_en.pdf

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