AstraZenica components (Vaxzevria COVID-19 vaccine)
- Chimpanzee Adenovirus encoding the SARS-CoV-2 Spike glycoprotein (ChAdOx1-S) * , not less than 2.5 × 108 infectious units (Inf.U)
- L-Histidine hydrochloride monohydrate
- Magnesium chloride hexahydrate
- Polysorbate 80 (E 433)
- Sodium chloride
- Disodium edetate (dihydrate)
- Water for injections
*Produced in genetically modified human embryonic kidney (HEK) 293 cells and by recombinant DNA technology.
These are multidose vials which contain 8 doses or 10 doses of 0.5 ml per vial. The suspension is colourless to slightly brown, clear to slightly opaque with a pH of 6.6.
Vaxzevria is a monovalent vaccine composed of a single recombinant, replication-deficient
chimpanzee adenovirus (ChAdOx1) vector encoding the S glycoprotein of SARS-CoV-2. The SARS-CoV-2 S immunogen in the vaccine is expressed in the trimeric pre-fusion conformation; the coding sequence has not been modified in order to stabilise the expressed S-protein in the pre-fusion conformation. Following administration, the S glycoprotein of SARS-CoV-2 is expressed locally 8 stimulating neutralising antibody and cellular immune responses, which may contribute to protection to COVID-19.